Should we switch MDD patient from SSRI to another SSRI if they are experiencing sexual dysfunction?
Incidence of sexual dysfunction across 12 antidepressants
DSM-5, The Diagnostic and Statistic Manual of Mental Disorders, Fifth Edition; MDD, Major depressive disorder.
Florido et al. ECNP 2019, Poster P.023.
In the prospective observational study conducted by Florido et al. on the incidence of sexual dysfunction across 12 commonly used antidepressants, the SSRIs fluoxetine and escitalopram were associated with lower incidences of sexual dysfunction compared to other SSRIs.1 In the instance where a patient is suffering from SSRI-induced sexual dysfunction, switching to another SSRI associated with lower incidences of sexual side effects may be possible. However, an alternative approach would be to switch to a multimodal antidepressant like Brintellix®(vortioxetine) which is associated with fewer sexual side effects compared to commonly used SSRIs and SNRIs.1,2
Brintellix® maintains efficacy in treating MDD while improving SSRI-induced sexual dysfunction, and is weight neutral
DSM-5, The Diagnostic and Statistic Manual of Mental Disorders, Fifth Edition; MDD, Major depressive disorder.
Florido et al. ECNP 2019, Poster P.023.
In the prospective observational study conducted by Florido et al. on the incidence of sexual dysfunction across 12 commonly used antidepressants, the SSRIs fluoxetine and escitalopram were associated with lower incidences of sexual dysfunction compared to other SSRIs.1 In the instance where a patient is suffering from SSRI-induced sexual dysfunction, switching to another SSRI associated with lower incidences of sexual side effects may be possible. However, an alternative approach would be to switch to a multimodal antidepressant like Brintellix®(vortioxetine) which is associated with fewer sexual side effects compared to commonly used SSRIs and SNRIs.1,2
Brintellix® maintains efficacy in treating MDD while improving SSRI-induced sexual dysfunction, and is weight neutral
The study included well-treated patients with MDD who were in remission for depressive symptoms but were experiencing sexual
dysfunction while being treated with citalopram, sertraline or paroxetine. CSFQ-14, Changes in Sexual Functioning Questionnaire; MARDS,
Montgomery–Åsberg Depression Rating Scale; MDD, major depressive disorder; SSRI, Selective serotonin reuptake inhibitor.
Jacobsen PL et al. J Sex Med 2015;12:2036–48.
Brintellix® improved sexual dysfunction in most dimensions and phases unlike other antidepressants
The study included well-treated patients with MDD who were in remission for depressive symptoms but were experiencing sexual
dysfunction while being treated with citalopram, sertraline or paroxetine. CSFQ-14, Changes in Sexual Functioning Questionnaire; MARDS,
Montgomery–Åsberg Depression Rating Scale; MDD, major depressive disorder; SSRI, Selective serotonin reuptake inhibitor.
Jacobsen PL et al. J Sex Med 2015;12:2036–48.
Brintellix® improved sexual dysfunction in most dimensions and phases unlike other antidepressants
CSFQ-14, Changes in Sexual Functioning Questionnaire; LS, Least squares; MMRM, mixed model for repeated measures.
Jacobsen PL et al. J Sex Med. 2015;12(10):2036–48.
In a double-blinded clinical trial of well-treated MDD patients experiencing SSRI-induced sexual dysfunction, Brintellix® was as effective as escitalopram in improving depressive symptoms, as measured by the MADRS, but was superior to escitalopram in improving SSRI-induced treatment-emergent sexual dysfunction in all 5 dimensions and 3 phases, as assessed using the CSFQ-14.2†
CSFQ-14, Changes in Sexual Functioning Questionnaire; LS, Least squares; MMRM, mixed model for repeated measures.
Jacobsen PL et al. J Sex Med. 2015;12(10):2036–48.
In a double-blinded clinical trial of well-treated MDD patients experiencing SSRI-induced sexual dysfunction, Brintellix® was as effective as escitalopram in improving depressive symptoms, as measured by the MADRS, but was superior to escitalopram in improving SSRI-induced treatment-emergent sexual dysfunction in all 5 dimensions and 3 phases, as assessed using the CSFQ-14.2†
† The study included well-treated patients with MDD who were in remission for depressive symptoms but were experiencing sexual
dysfunction while being treated with the SSRIs citalopram, sertraline or paroxetine.
Abbreviations
SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin norepinephrine reuptake inhibitor; MDD, major depressive disorder; MADRS,
Montgomery-Åsberg Depression Rating Scale; CSFQ-14, Changes in Sexual Functioning Questionnaire Short Form
† The study included well-treated patients with MDD who were in remission for depressive symptoms but were experiencing sexual
dysfunction while being treated with the SSRIs citalopram, sertraline or paroxetine.
Abbreviations
SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin norepinephrine reuptake inhibitor; MDD, major depressive disorder; MADRS,
Montgomery-Åsberg Depression Rating Scale; CSFQ-14, Changes in Sexual Functioning Questionnaire Short Form