What are the roles of abnormal metabolism and inflammation in mood disorders?

Inflammation and abnormal metabolism are observed in major depressive and bipolar disorders, said Professor Roger McIntyre of the University of Toronto, in a keynote plenary presentation for the ISBD 2020 virtual conference. The abnormalities result from both genetic and epigenetic factors and have been shown to impact both cognition and rewarding domains in the brain — which are both implicated in the pathophysiology of mood disorders.

 

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02:54
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Our correspondent’s highlights from the symposium are meant as a fair representation of the scientific content presented. The views and opinions expressed on this page do not necessarily reflect those of Lundbeck.

References
  1. Mansur RB, et al. J Psychiatr Res 2018;107:128–35.
  2. Mansur RB, et al. Ann Clin Psychiatry 2018;30:38–50.
  3. Kleinridders A, et al. Proc Natl Acad Sci USA 2015;112:3463–8.
  4. Depp CA, et al. Bipolar Disord 2014;16:422–31.
  5. Eisenstein SA, et al. PLoS One 2015;10:e0133621.
  6. Chen V C-H, et al. Neuropsychiatr Dis Treat 2018;14:3199–208.
  7. Salzwedel AP, et al. Front Hum Neurosci 2019;12:514.
  8. Felger JC, et al. Mol Psychiatry 2016;21:1358–65.
  9. Felger JC, Threadway MT. Neuropsychopharmacology 2017;42:216–41.
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