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Time lost providing patients with migraine with effective treatment is time lost for the patient’s quality of life, family life, and life opportunities, said experts at the Migraine Trust International Symposium 2022. Increasing evidence over time on the effectiveness and tolerability of calcitonin gene-related peptide pathway monoclonal antibody treatment is leading to changing times in migraine management.
The importance of time in patient management
The Chronic Migraine Epidemiology and Outcomes (CAMEO) Study details the large amount of time lost to patients due to barriers in care, said Professor Teshamae Monteith, Miami, FL.1
Too many people are underdiagnosed and undertreated or inappropriately treated
These barriers include lack of appropriate medical consultation, failure to receive an accurate diagnosis, not being offered appropriate acute and preventive pharmacologic treatments when indicated, and not avoiding medication overuse.1
Too many people are underdiagnosed and undertreated or inappropriately treated, said Professor Monteith, who also highlighted:
The interictal burden has a negative impact on health-related quality of life3
Compared with oral SOC at Month 12, patients treated with CGRP pathway mAb were 6.48 times more likely to stay on treatment and achieve ≥50% reduction in MMD4
Is it time to APPRAISE our approach to migraine prophylaxis?
Dr Patricia Pozo-Rosich, Barcelona, Spain, presented the results of the APPRAISE trial — the first global, pragmatic,12-month prospective, randomized, active-controlled, Phase 4, open-label trial evaluating the long-term benefit of a calcitonin gene-related peptide (CGRP) pathway monoclonal antibody (mAb) treatment versus oral standard-of-care (SOC) preventives. All patients had episodic migraine and had failed one or two previous migraine preventives.4
Compared with oral SOC, patients treated with CGRP pathway mAb were 13.75 times more likely to achieve a relevant clinical improvement at Month 124
Compared with patients treated with SOC oral preventives, patients treated with the CGRP pathway mAb were:
Compared with oral SOC, patients treated with CGRP pathway mAb were much less likely to discontinue treatment due to adverse events (2.9% vs 23.3%)4
Assessing the evidence for CGRP mAbs: What has time told us?
Professor Dagny Holle-Lee, Essen, Germany, presented the results of studies that answer patients’ questions about the use of CGRP pathway mAb treatment as follows:
CGRP pathway mAbs are effective in some patients with drug-resistant migraine and chronic daily headache7
Changing times in migraine management: How do guidelines help?
The updated EHF guideline suggests that CGRP pathway mAbs are included as a first line treatment option for migraine requiring preventive treatment9
CGRP pathway mAbs have changed the migraine treatment paradigm with more timely treatment improving outcomes, said Professor Simona Sacco, L’Aquila, Italy.
The European Headache Federation (EHF) guideline has therefore been updated and now suggests that CGRP pathway mAbs are included as a first line treatment option for individuals with migraine who require preventive treatment.9
This symposium was organized and funded by Novartis
Our correspondent’s highlights from the symposium are meant as a fair representation of the scientific content presented. The views and opinions expressed on this page do not necessarily reflect those of Lundbeck.