Sleep Architecture in Patient with Alzheimer’s Disease

People with Alzheimer’s Disease often have problems with sleeping or may experience changes in their sleep schedule and need to be a concern. Scientists do not completely understand why these sleep disturbances occur as with changes in memory and behavior, sleep changes somehow result from the impact of Alzheimer’s on the brain. It is said that people who have difficulty to sleep when young tend to experience Alzheimer's Disease in old age. On the contrary, Alzheimer's Disease patients with Tau and Amyloid accumulation tend to damage brain tissues that play a role in sleep, Tau in Hypothalamus occurs in pre-clinic before there are symptoms of Alzheimer's Disease, there it says that Tau interferes with the function of the Sleep Homosense Center, which should inhibit the level so that people are sleepy, but this is not, so that Alzheimer's Disease patients wake up more than sleep. Amyloid further destroys the Circadian cycle, and also the Pineal Body reduces production Melatonin that is essential for sleep. So, this is very important, we begin to explore, especially in Neurology which treats Alzheimer's Disease patients.


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