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Welcome to Progress in Mind’s live coverage of ECNP 2021. This 34th Congress of the European College of Neuropsychopharmacology – Lisbon 2021 continued today, October 3rd, with congress attendees getting morning program onsite to be joined by remote attendees online at lunchtime. Today’s presentations ranged from new findings in schizophrenia, depression and Alzheimer’s disease along with how new technologies are helping explain neurobiology in health and disease. Here is a summary of today’s (Day 2) highlights from this interesting, often discussion led Sunday in Lisbon.
Unmet needs in psychiatric conditions
Five satellite symposia included discussion of:
There are still many unmet needs in treatment for depression, schizophrenia and insomnia
Five ‘Campfire Sessions’ allowed more intimate discussion on:
The hybrid conference may be here to stay
Talking about COVID-19, in vitro models and new targets in Alzheimer’s disease
Three ‘Brainstorming Sessions’ delivered short presentations followed by longer discussions:
There are worrying amounts of new psychiatric conditions, including depression and anxiety, following COVID-19 infection
The latest findings in Attention Deficit and Hyperactivity Disorder (ADHD), memory, emotional regulation and pregnancy
Six symposium tackled some key issues in psychiatric conditions:
New technologies are revealing the neurobiology of memory, stress, and pregnancy
Professor Carmen Sandi’s Plenary Lecture focused on the involvement of mitochondrial function and metabolism in the nucleus accumbens, the brain’s ‘motivational hub,’ which has led to an understanding of stress vulnerability and depression and anxiety comorbidity.8
Dr. Annamaria Cattaneo’s Plenary Lecture examined the circumstances under which early life stress exposure can lead to development of psychiatric disorders and the molecular mechanisms of such.
‘Interactive Format’ sessions gave attendees a chance to hear and chat about peoples’ experiences as researchers and clinicians; gender and diversity issues in brain sciences;9 and digital phenotyping in mental health.
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Our correspondent’s highlights from the symposium are meant as a fair representation of the scientific content presented. The views and opinions expressed on this page do not necessarily reflect those of Lundbeck.
1. Gorwood, P.; Bouju, S.; Deal, C.; Gary, C.; Delva, C.; Lancrenon, S.; Llorca, P. M. Predictive factors of functional remission in patients with early to mid-stage schizophrenia treated by long acting antipsychotics and the specific role of clinical remission. Psychiatry Res 2019, 281, 112560.
2. Prevention and Remediation of Insulin Multimorbidity in Europe. https://prime-study.eu/.
3. Taquet, M.; Geddes, J. R.; Husain, M.; Luciano, S.; Harrison, P. J. 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. Lancet Psychiatry 2021, 8, 416-427.
4. Hartlaub, A. M.; McElroy, C. A.; Maitre, N. L.; Hester, M. E. Modeling Human Brain Circuitry Using Pluripotent Stem Cell Platforms. Frontiers in Pediatrics 2019, 7.
5. Neff, R. A.; Wang, M.; Vatansever, S.; Guo, L.; Ming, C.; Wang, Q.; Wang, E.; Horgusluoglu-Moloch, E.; Song, W.-m.; Li, A.; Castranio, E. L.; TCW, J.; Ho, L.; Goate, A.; Fossati, V.; Noggle, S.; Gandy, S.; Ehrlich, M. E.; Katsel, P.; Schadt, E.; Cai, D.; Brennand, K. J.; Haroutunian, V.; Zhang, B. Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets. Science Advances 2021, 7, eabb5398.
6. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell 2019, 179, 1469-1482.e1411.
7. Wasserman, D.; Hoven, C. W.; Wasserman, C.; Wall, M.; Eisenberg, R.; Hadlaczky, G.; Kelleher, I.; Sarchiapone, M.; Apter, A.; Balazs, J.; Bobes, J.; Brunner, R.; Corcoran, P.; Cosman, D.; Guillemin, F.; Haring, C.; Iosue, M.; Kaess, M.; Kahn, J. P.; Keeley, H.; Musa, G. J.; Nemes, B.; Postuvan, V.; Saiz, P.; Reiter-Theil, S.; Varnik, A.; Varnik, P.; Carli, V. School-based suicide prevention programmes: the SEYLE cluster-randomised, controlled trial. Lancet 2015, 385, 1536-1544.
8. Gebara, E.; Zanoletti, O.; Ghosal, S.; Grosse, J.; Schneider, B. L.; Knott, G.; Astori, S.; Sandi, C. Mitofusin-2 in the Nucleus Accumbens Regulates Anxiety and Depression-like Behaviors Through Mitochondrial and Neuronal Actions. Biol Psychiatry 2021, 89, 1033-1044.
9. Thibaut, F. The role of sex and gender in neuropsychiatric disorders. Dialogues Clin Neurosci 2016, 18, 351-352.